job description
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The PhD researcher will study single cell biophysics in early metastasis. Passionate about biophysics and cancer research? Join us as we shed light on the role of single cell mechanics in metastatic disease! We are looking for a skilled PhD researcher to reveal biophysical disease markers using Atomic Force Microscopy (AFM) and Fluid Force Microscopy (FluidFM) techniques.
Mac4Me (Macrophage Targets for Metastatic Therapeutics) is a pan-European Marie Skłodowska-Curie Doctoral Network (DC) of 18 PhD candidates aiming to understand metastatic site-specific tumor cell-immune host interactions to identify novel immune targets.Mac4Me will use an animal-free organ-on-a-chip (OoC) system to recapitulate early stage tumor cell-immunity interactions in neuroblastoma, breast cancer and prostate cancer and other cancers with early liver metastases, bone metastases and brain metastases. Data from these preclinical models will be combined with real-world clinical data through artificial intelligence methods to identify new immune targets.Mac4Me offers a unique and innovative research training program that encompasses both scientific knowledge and transferable skills, with participatory science principles as a starting point.
At TU Delft, you will focus on the biophysics of single cells in the context of early cancer metastasis. The goal is to quantify the shape, size, mechanical properties and adhesion strength of individual cancer and immune cells to discover potential biophysical disease markers. Experiments will be performed using atomic force microscopy and hydrodynamic microscopy methods on existing state-of-the-art bio-atomic force microscopy instruments. Efficient integrated measurements will be performed using a new patented multifunctional microfluidic AFM probe. Suitable analytical models will be developed in collaboration with other partners in the network to analyze the data and interpret the results. Analytical frameworks such as RHEOS software, finite element modeling, and machine learning concepts will be explored with collaborators to process the large data sets generated.
This position is part of the Micron and Nano Engineering (MNE) department in the Faculty of Mechanical Engineering, Department of Precision and Microsystems Engineering at Delft University of Technology. You will join the research group led by Dr. Murali Ghatkesar to develop novel precision microfluidic tools to quantify and understand single-cell (and subcellular) biophysics. In the department, you will work with PhD students and postdocs in micromachining, nanomechanics, biophysics and precision measurements. You will be trained to use our high-tech laboratory facilities, including high-resolution 3D printers, advanced optical microscopes (including confocal microscopes, scanning electron microscopes), state-of-the-art bio-atomic force microscopes, micro-Raman spectroscopy, profilometers and several other characterization tools. There is also a state-of-the-art clean room and a brand new biosafety level 2 laboratory. During your research, you will work closely with PhD and postdoctoral researchers at the Erasmus Medical Center, the Politecnico di Milano and the Technical University of Dresden. As part of your research, you will have the opportunity to visit your collaborators on a 3-6 month secondment.
Regular interaction with interdisciplinary experts fosters scientific growth and career development. An open and collaborative environment encourages daily knowledge exchange with minimal hierarchical barriers, ensuring strong mentoring and tailored training. Professional growth is a priority, ensuring your success in scientific research.
offer requirements
Master’s degree in Mechanical Engineering, Applied Physics, or Nanotechnology with a specialization in Micron/Nano Engineering, Biophysics, Bionanoscience, or Bioengineering;
Experience in more than one of the following areas: atomic force microscopy (AFM)/spectroscopy, statistical data analysis, biophysics, finite element simulation, analytical modeling, microfluidics, and micromachining;
Strong interest in single-cell biophysics and cancer research;
Excellent experimental, analytical and problem solving skills;
Self-driven attitude, creativity and autonomy;
Strong written and oral communication skills in English;
Agile and collaborative skills.
The following points will make you stand out:
Creative, open-minded and proactive researcher;
Excellent experimental and analytical skills;
Ability to work in a team and independently.
offer benefits/salary
The PhD candidate will in principle be offered a 4-year appointment, but in the form of 2 employment contracts. The first contract will be for 1.5 years with a formal go/no-go progress assessment within 15 months. If all goes well and performance requirements are met, a supplementary contract of 2.5 years is signed.
Salary and benefits are in accordance with the Dutch University Collective Labor Agreement and increase from €2,872 per month in the first year to €3,670 in the fourth year. As a PhD student, you will be enrolled in the Graduate School of Delft University of Technology. The Graduate School of Delft University of Technology has an excellent team of supervisors, academic staff and mentors to provide you with an inspiring research environment. The doctoral education program is designed to develop your transferable, discipline-relevant and research skills.
Delft University of Technology offers customizable remuneration packages, discounts on health insurance and a monthly allowance for work expenses. Flexible working hours can be arranged.
For international applicants, TU Delft offers the “Come to Delft Service”. This service provides new international employees with information to help you prepare for relocation and settle down in the Netherlands. The Come to Delft Service offers dual career programs for partners and organizes events to expand your (social) network.