job description
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The selected candidate will conduct translational doctoral research under the supervision of Prof. An Jacobs, Prof. Frank Claessens, and Prof. Lies Langouche. The candidate will join the Intensive Care Medicine laboratory and collaborate with the Molecular Endocrinology laboratory, both affiliated with the Department of Cellular and Molecular Medicine at KU Leuven (Belgium).
The Intensive Care Medicine laboratory is a multidisciplinary, translational basic/clinical research team that combines research laboratory and clinical input. This unique combination enables effective cross-talk between patient studies, animal models, and molecular research. The Molecular Endocrinology laboratory focuses on the mechanisms by which androgens regulate transcription in different cell types, and how this leads to effects on reproduction, the prostate, musculoskeletal system, and other organs. They use biochemical, molecular, cellular, genetic, and in vivo approaches to study the function and mechanisms of androgen receptors in cells, animal models, and humans.
The aim of this project is to further elucidate the pathophysiological mechanisms, prediction, and treatment options of Polycystic Ovary Syndrome (PCOS). PCOS is the most common endocrine disorder affecting women of reproductive age, with effects spanning the entire life cycle from puberty to post-menopause. The clinical presentation is highly heterogeneous, including reproductive aspects (ovulatory dysfunction, irregular menstruation and infertility, hyperandrogenemia), metabolic aspects (obesity, insulin resistance, and abnormal lipid levels), as well as psychological features. The pathogenesis is complex and not yet fully understood, but emerging evidence suggests that potential biological mechanisms are not limited to the reproductive period.
Through a clinical study investigating the peripubertal period in neonates at risk of developing PCOS, as well as a PCOS mouse model, we aim to explore the peripubertal period as a ‘window of opportunity’ for the prediction and treatment of PCOS.
offer requirements
– Highly motivated, enthusiastic, critical, and creative individuals with a relevant Master’s degree or equivalent, such as Medicine, Biomedical Sciences, Biomedical Engineering, Biochemistry, Biology (or similar degrees).
– Excellent oral and written communication skills.
– Enjoy working independently as well as in a team.
– Fluent in English.
– Fluency in Dutch is an asset (due to possible patient contact).
offer benefits/salary
– Work in an internationally recognized team of experts in endocrinology and metabolic research, which is a multidisciplinary translational research group.
– Access to state-of-the-art research facilities and enrollment in a specific doctoral school program.