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Celiac Disease and Diabetes PhD Students Program Description Lund University was founded in 1666 and has been ranked among the world’s leading universities many times. The university has approximately 47,000 students and more than 8,800 faculty members in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition. Lund University welcomes applicants with diverse backgrounds and experiences. We see gender equality and diversity as a strength and an asset. Job Description The Celiac Disease and Diabetes Research Group at the Department of Clinical Sciences in Malmö focuses on autoimmune diabetes, celiac disease and autoimmune thyroid inflammation, as well as other uncommon autoimmune diseases such as narcolepsy. The research has been at the forefront of the field of celiac disease and diabetes for several years. The group is currently led by adjunct professor Daniel Agardh and consists of researchers and technicians. For more information on the study, click here. The group is located at the Clinical Research Center (CRC) in Malmö. We are committed to creating a positive, respectful and stimulating environment. We value communication and collaboration and a work environment that promotes learning and development for all staff. We are also committed to creating a safe and positive environment for all employees through mutual respect and tolerance. PhD Research Topics Medical Science Program Description This program is a population-based screening program for Type 1 Diabetes (T1D), Celiac Disease (CD), and Autoimmune Thyroid Disease (AITD) in children. The goal of screening is to identify asymptomatic cases for early intervention and improved prognosis. A scalable model was developed to integrate advanced laboratory diagnostic methods for these three diseases. Advances in laboratory technology have revolutionized screening for T1D, CD and AITD. Automated platforms enable precise autoantibody measurements in large populations at minimal cost and effort, improving diagnostic accuracy and enabling analysis of large numbers of samples. These tools are critical to the success of future mass screening programs. The purpose of this project is to utilize biomedical laboratory science techniques to further public screening for T1D, CD and AITD in children. In addition, the project will develop patient-specific in vitro disease models to better understand the molecular mechanisms behind autoimmunity. The project combines laboratory techniques with stem cell research to improve screening methods and deepen the understanding of autoimmune diseases in children. Job Responsibilities The main task of a PhD student is to devote yourself fully to your doctoral education, so you are both a student and an employee of Lund University. Specifically, the project involves assessing the diagnostic accuracy of filter paper blood samples versus traditional blood collection samples. The analysis will be performed using a multiplex ADAP method to simultaneously detect insulin, GAD65, ZnT8, IA-2, tTGA and TPO autoantibodies. In addition, the program will evaluate autoantibody affinity as a potential early biomarker of progression from autoimmune activation to clinical disease. As part of the study, skin or white blood cell samples will be collected to generate pluripotent stem cells in collaboration with the BMC Stem Cell Therapy Center in Lund. These stem cells will be gene edited using CRISPR/Cas technology to allow transcriptional and functional comparisons of homologous cell lines. Another important aspect of the project is the development of patient-specific co-cultures of small intestinal organoids with immune cells, with the goal of determining the precise autoimmune mechanisms of gluten exposure. Other tasks may be assigned by the research team.
offer requirements
Eligibility Applicants must meet the following criteria to be eligible for the Ph.D. degree: have earned an advanced degree, have completed at least 240 credits of course requirements, of which at least 60 credits are at the advanced level, or have otherwise gained substantially equivalent knowledge either domestically or abroad have a demonstrated ability to utilize graduate education good ability Employment Requirements Bachelor’s and/or Master’s Degree in Biomedical Sciences, Molecular Biology, or the equivalent. . Laboratory experience is required. Strong emphasis is placed on personal qualities as the work requires independence, precision, strong organizational and collaborative skills, social skills, and a results-oriented and proactive attitude. Excellent candidates for this position include those with laboratory experience related to T1D, CD and AITD preferred. It is important that applicants are evaluated on how well their experience and abilities are assessed as having the competencies required to complete the PhD program. The regulations governing the employment of doctoral students can be found in Regulation SFS 1998:80. Only those who have been admitted to the PhD program may be appointed to the doctoral program. The main criterion for selection is the applicant’s ability to successfully complete the PhD. In addition to working on their own research education, the incumbent of the position may be assigned to teaching, research and administrative work as defined in the regulation.
offer benefits/salary
What we offer Lund University is a public university, which means you’ll enjoy exceptional employment advantages, generous leave entitlements and a favorable occupational pension scheme. Visit the Lund University website to find out more about working at Lund University.