job description
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Being a PhD student means being fully engaged in a research project under the supervision of an experienced researcher and following an individual study plan. Obtaining a PhD requires the equivalent of four years of full-time doctoral education. Students will work and receive training in the Qian Hong group in the Center for Hematology and Regenerative Medicine (HERM) in the Department of Medicine at Huddinge. The research group aims to unravel the role of the leukemic microenvironment/niche in the progression of myeloid leukemias, including acute and chronic myeloid leukemias (AML and CML), and in drug response. The ultimate goal is to identify novel niche-based therapeutic targets to improve disease outcomes. To date, the group has identified a range of molecules that are dysregulated in the leukemic ecological niche using patient and mouse models. Key techniques used include multicolor flow cytometry, confocal imaging, lineage tracing, in vitro and in vivo stem cell assays (including co-culture and transplantation), and molecular tools (e.g., RNA sequencing, digital PCR, and single-cell PCR).
offer requirements
This project will focus on evaluating the functional effects of several newly discovered leptokines in acute myeloid leukemia (AML) (Xiao et al., Blood Adv., 2018a and 2018b; Cai et al., Blood, 2022), a devastating disease with poor treatment outcomes. The PhD program will be conducted under the guidance of the primary supervisor, Hong Qian, and co-supervisors Arnika Kathleen Wagner (specializing in immune cell regulation and therapy) and Muhammad Kashif (specializing in bioinformatics analysis, including RNA sequencing and programming). Students will have the opportunity to learn theoretical knowledge and research methods. Students will learn how to formulate specific hypotheses and test hypotheses in this project by using mouse models of AML and patient samples in combination with commercially available recombinant peptides or CRISPR/Cas9 gene editing strategies under the guidance of their mentors and in collaboration with experts/hematologists in the field. In addition, students will participate in other collaborative projects related to this program. No later than the application deadline, you must meet the following general (A) and specific (B) eligibility requirements to be selected for a PhD position. It is your responsibility to qualify as described on the PhD Entry Requirements (Eligibility) webpage.A) General Eligibility RequirementsThe general eligibility requirements for a PhD/Third Cycle/Doctoral education are met if you meet the following: have earned a Stage II/Advanced Stage/Master’s degree (i.e., M.S. degree) or have met the course requirements for a minimum of 240 credits of which a minimum of 60 credits were earned at the Advanced/ Stage II/Master’s level, or have otherwise acquired substantially equivalent knowledge in Sweden or abroad*. Please follow the instructions on the webpage for admission requirements (qualifications) for doctoral education. *If you claim to have equivalent knowledge, please follow the instructions on the webpage.B) Specific eligibility requirementsSpecific eligibility requirements for doctoral/third-cycle/doctoral education are met if you meet the following conditions:- English proficiency equivalent to Swedish upper secondary school English grade B/English grade 6. Please follow the instructions on the webpage on English language requirements for doctoral education. Verification of documents Karolinska Institutet verifies the authenticity of the documents. Karolinska Institutet reserves the right to cancel an offer of admission if the supporting documents are found to be false. Submitting false documents is a violation of Swedish law and will be prosecuted. (A) and (B) can only be proven through the documentation requirements for doctoral education. We are looking for a highly motivated, responsible and organized candidate. The applicant must be able to work flexibly in a high-paced research environment. Candidates are expected to have good oral and written English, strong organizational skills, and experience with mice, flow cytometry, and cell culture (especially co-culture with MSCs). Eligible applicants should hold a Master’s degree in medicine, biomedicine, molecular biology and translational research. Personal competence will be an important selection criterion.
offer benefits/salary
An innovative and stimulating environment full of expertise and curiosity. Karolinska Medical School is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote health for all. At Karolinska Institutet of Medicine, we conduct successful medical research and have the largest medical education organization in Sweden. As a PhD student, you will have access to an independent research program, a well-educated supervisor, a large number of elective courses and the opportunity to work in a leading research group. Karolinska Institutet’s cooperation with leading universities around the world ensures opportunities for international exchange. You will be employed as a PhD student, which means you will receive a contractual salary. Employees also have free access to our modern gym and are reimbursed for medical expenses. PhD students will be employed on a doctoral fellowship for a maximum period of 4 years, full-time.