job description
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Being a PhD student means being fully engaged in a research project under the supervision of experienced researchers and following an individual study plan. Obtaining a PhD requires the equivalent of four years of full-time doctoral education.
This position is part of the Ioannis Parodis Research Group at the Faculty of Medicine in Solna. Our research aims to improve the diagnosis, monitoring and management of patients with systemic lupus erythematosus. Our research focuses on identifying biomarkers that reflect lupus activity and predict flares, response or non-response to treatment (especially B-cell targeted therapies), and long-term efficacy. We emphasize patient-reported health status and patient engagement in medical care.
The Solna Faculty of Medicine is one of the largest departments at Karolinska Institutet of Medicine. It provides clinical and undergraduate education as well as research education for medical and biomedical students and currently has more than 200 registered PhD students. We carry out cutting-edge research in various biomedical fields. One of the main strengths of the Department is its proximity to patients, which creates excellent opportunities to combine basic research with patient-centered research in a clinical setting.
The program aims to explore the molecular mechanisms that contribute to susceptibility to autoimmune diseases, focusing on the genetics and genomics of the HLA locus. The successful candidate will be responsible for developing and adapting a work plan aligned with the project objectives, designing and conducting wet lab experiments and computational experiments, and analyzing the results. Regular discussions with the supervisor and team members will be essential to refine objectives, finalize results, draft manuscripts, and prepare for publication. Throughout the Ph.D. program, Ph.D. students are expected to take required courses in genetics, immunology, and bioinformatics and relevant supplemental courses. Active participation in the scientific network of the department and Karolinska Institutet of Medicine is essential, including participation in international collaborations.
offer requirements
At the latest by the application deadline, you must fulfill the following general (A) and specific (B) eligibility requirements to be selected for a PhD position.
It is your responsibility to qualify as described on the PhD Entry Requirements (Eligibility) webpage.
A) GENERAL ELIGIBILITY REQUIREMENTS You meet the general eligibility requirements for the Ph.D./Third Cycle/Ph.D. education if you meet the following:
Have earned a Stage II/Advanced Stage/Master’s Degree (i.e., a Master’s Degree), or
have fulfilled the program requirements of at least 240 credits, of which at least 60 credits were earned at the advanced/second stage/master’s level, or
have otherwise acquired substantially equivalent knowledge in Sweden or abroad*.
Please follow the instructions on the webpage for admission requirements (qualifications) for doctoral education.
*If you claim to have equivalent knowledge, please follow the instructions on the webpage.
B) Specific Qualification Requirements
You meet the Specific Eligibility Requirements for Doctoral/Third Cycle/Doctoral Education if you meet the following conditions:
– A level of English equivalent to Swedish upper secondary English grade B/English 6.
Please follow the instructions for the English language requirements for doctoral education on the webpage.
Verification of documents Karolinska Institutet verifies the authenticity of the documents. Karolinska Institutet reserves the right to cancel an offer of admission if the supporting documents are found to be false. Submitting false documents is a violation of Swedish law and is punishable by law.
(A) and (B) can only be proved by documentation requirements for doctoral education.
The ideal candidate should have a solid foundation in bioinformatics for genetic and transcriptome analysis, including proficiency in single-cell analysis. Required skills include proficiency in R and Python programming. Must have wet lab experience including experimental work with human cell lines and primary blood cells, sample preparation for DNA and RNA high volume and single cell sequencing, generation of recombinant constructs, and ex vivo and in vivo functional studies of human blood cells. Proficiency in immunological assays such as ELISA, Western blotting and flow cytometry is essential. Knowledge of HLA structure and function is highly desirable.
Candidates must have experience working in an international environment, demonstrating strong interpersonal skills as well as the ability to work independently. Additionally, the ability to adapt to changing environments or approaches and meet challenges, as well as the ability to objectively analyze information and make informed decisions, are also critical. Ideal attributes include a willingness to take a leadership role and independently drive projects forward, as well as strong organizational skills and efficient time management.
offer benefits/salary
An innovative and stimulating environment filled with expertise and curiosity. Karolinska Medical School is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote health for all. At Karolinska Institutet of Medicine, we conduct successful medical research and have the largest medical education organization in Sweden. As a PhD student, you will have access to an independent research program, a well-educated supervisor, a large number of elective courses and the opportunity to work in a leading research group. Karolinska Institutet’s cooperation with leading universities around the world ensures opportunities for international exchange. You will be employed as a PhD student, which means you will receive a contractual salary. Employees also have free access to our modern gym and are reimbursed for medical expenses.
PhD students will be employed on a doctoral fellowship for a maximum period of 4 years, full-time.