job description
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PhD student position in receptor pharmacology of metabolic dysfunction-associated steatohepatitis
Project description
Do you want to contribute to the improvement of human health?
Becoming a Ph.D. student means being fully engaged in a research project under the guidance of an experienced researcher and following an individual study plan. Obtaining a PhD requires the equivalent of four years of full-time doctoral education.
Research Teams
Successful candidates will join a team led by Shane Wright, Assistant Professor in the Department of Physiology and Pharmacology. His team studies the pharmacology of the G protein-coupled receptor (GPCR), an important drug target. The overarching theme of the lab is to better understand and utilize GPCR signaling to design safer drugs for patients.
Ph.D. Project and Ph.D. Responsibilities
This Ph.D. project will investigate the role of GPCR in metabolic dysfunction-associated steatohepatitis (MASH), a form of inflammatory steatohepatitis for which there are currently only limited pharmacological treatment options. The research will utilize organ models of MASH to screen compounds against GPCR to identify novel targets for disease intervention. The PhD student will utilize subcellular biosensors to elucidate the similarities and differences between different targets to better understand the molecular basis of anti-MASH action. Histology-based approaches will translate molecular findings into functional mechanisms that will be used for further validation. At the end of this project, we will have discovered new disease targets and deepened our understanding of the signaling networks that address the MASH disease signature. Students are expected to play a significant role in hypothesis formulation, experimental design, experimentation, data analysis, presentation of results at meetings and conferences, and manuscript writing. Students are responsible for adhering to the general regulations and time schedule of the PhD program.
What do we offer?
A creative and stimulating environment full of expertise and curiosity. Karolinska Medical School is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote health for all. At Karolinska Institutet of Medicine, we conduct successful medical research and have the largest medical education institution in Sweden. As a PhD student, you will have access to an independent research program, a well-educated supervisor, a large number of elective courses and the opportunity to work in a leading research group. Karolinska Institutet’s cooperation with leading universities around the world ensures opportunities for international exchange. You will be employed as a PhD student, which means you will receive a contractual salary. Employees also have free access to our modern gym and are reimbursed for medical expenses.
Eligibility requirements for PhD students
By the application deadline at the latest, you must meet the following general (A) and specific (B) eligibility requirements in order to be selected for a PhD position.
It is your responsibility to qualify as described on the PhD Entry Requirements (Eligibility) webpage.
A) GENERAL ELIGIBILITY REQUIREMENTS The general eligibility requirements for a PhD/third cycle/doctoral education are met if you
have obtained a Stage II/Advanced Stage/Master’s degree (i.e., Master’s Degree) or
have fulfilled the requirements for a program of at least 240 credits, of which at least 60 credits have been obtained at the Advanced Stage/Second Stage/Master’s level or
Please follow the instructions on the webpage for admission requirements (qualifications) for doctoral education.
*If you claim to have equivalent knowledge, please follow the instructions on the webpage.
B) Specific Eligibility Requirements
Specific eligibility requirements for doctoral/third-cycle/doctoral education are met if you meet the following conditions:
– English proficiency equivalent to Swedish upper secondary school English level B/English level 6.
Please follow the instructions on the webpage for English language requirements for doctoral education.
Checking of documents Karolinska Institutet checks the authenticity of the documents. Karolinska Institutet reserves the right to cancel an offer of admission if the supporting documents are found to be false. Submission of false documents is a violation of Swedish law and will be prosecuted.
(A) and (B) can only be proved by documentation requirements for doctoral education.
Skills and personal qualities
We are looking for a highly motivated and talented student with a strong interest in receptor pharmacology and drug development. Applicants should have good communication skills and be able to work both independently and in a team environment. Preference will be given to candidates with experience working with RET-based biosensors and 3D cell culture.
Terms and conditions
The PhD student will be employed on a PhD Fellowship for a maximum period of 4 years, full-time.
Application Procedure
Submit your application and supporting documents through the Varbi Recruitment System. Use the button in the upper right corner and follow the instructions. We prefer that you submit your application in English, but you can also submit your application in Swedish.
Your application must contain the following documents
– A personal letter and curriculum vitae – Degree programs and previous publications (if any) – Any other documents demonstrating the desirable skills and personal qualities listed above – Documents demonstrating your general qualifications (see section A above) – Documents demonstrating your specific qualifications (see section B above)
Selection
Selection will be made from amongst qualified applicants on the basis of whether the applicant will be able to graduate from a doctoral program. Selection will be made from among eligible applicants on the basis of their ability to benefit from a doctoral education. The qualifications of the applicants will be thoroughly evaluated.
The Karolinska Institutet of Medicine uses the following bases for assessment:
– Documented disciplinary knowledge relevant to the field of study – Analytical skills – Other documented knowledge or experience relevant to doctoral research in the discipline.
All applicants will be notified after the recruitment process.
It is your responsibility to qualify as described on the PhD Entry Requirements (Qualifications) webpage.
A) GENERAL ELIGIBILITY REQUIREMENTS The general eligibility requirements for a PhD/third cycle/doctoral education are met if you
have obtained a Stage II/Advanced Stage/Master’s degree (i.e., Master’s Degree) or
have fulfilled the requirements for a program of at least 240 credits, of which at least 60 credits have been obtained at the Advanced Stage/Second Stage/Master’s level or
Please follow the instructions on the webpage for admission requirements (qualifications) for doctoral education.
*If you claim to have equivalent knowledge, please follow the instructions on the webpage.
B) Specific Eligibility Requirements
Specific eligibility requirements for doctoral/third-cycle/doctoral education are met if you meet the following conditions:
– English proficiency equivalent to Swedish upper secondary school English level B/English level 6.
Please follow the instructions on the webpage for English language requirements for doctoral education.
Checking of documents Karolinska Institutet checks the authenticity of the documents. Karolinska Institutet reserves the right to cancel an offer of admission if the supporting documents are found to be false. Submission of false documents is a violation of Swedish law and will be prosecuted.
(A) and (B) can only be proved by documentation requirements for doctoral education.
We are looking for an outstanding, motivated student with a strong interest in receptor pharmacology and drug development. The applicant should have good communication skills and be able to work both independently and in a team environment. Preference will be given to candidates with experience working with RET-based biosensors and 3D cell culture.
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offer requirements
No later than the application deadline, you must meet the following general (A) and specific (B) eligibility requirements in order to be considered for selection for a PhD position.
It is your responsibility to qualify as described on the PhD Entry Requirements (Eligibility) webpage.
A) GENERAL ELIGIBILITY REQUIREMENTS The general eligibility requirements for a PhD/third cycle/doctoral education are met if you
have obtained a Stage II/Advanced Stage/Master’s degree (i.e., Master’s Degree) or
have fulfilled the requirements for a program of at least 240 credits, of which at least 60 credits have been obtained at the Advanced Stage/Second Stage/Master’s level or
Please follow the instructions on the webpage for admission requirements (qualifications) for doctoral education.
*If you claim to have equivalent knowledge, please follow the instructions on the webpage.
B) Specific Eligibility Requirements
Specific eligibility requirements for doctoral/third-cycle/doctoral education are met if you meet the following conditions:
– English proficiency equivalent to Swedish upper secondary school English level B/English level 6.
Please follow the instructions on the webpage for English language requirements for doctoral education.
Checking of documents Karolinska Institutet checks the authenticity of the documents. Karolinska Institutet reserves the right to cancel an offer of admission if the supporting documents are found to be false. Submission of false documents is a violation of Swedish law and will be prosecuted.
(A) and (B) can only be proved by documentation requirements for doctoral education.
We are looking for an outstanding, motivated student with a strong interest in receptor pharmacology and drug development. The applicant should have good communication skills and be able to work both independently and in a team environment. Preference will be given to candidates with experience working with RET-based biosensors and 3D cell culture.
offer benefits/salary
An innovative and stimulating environment full of expertise and curiosity. Karolinska Medical School is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote health for all. At Karolinska Institutet of Medicine we conduct successful medical research and have the largest medical education organization in Sweden. As a PhD student, you will have access to an independent research program, a well-educated supervisor, a large number of elective courses and the opportunity to work in a leading research group. Karolinska Institutet’s cooperation with leading universities around the world ensures opportunities for international exchange. You will be employed as a PhD student, which means you will receive a contractual salary. Employees also have free access to our modern gym and are reimbursed for medical expenses.