job description
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The Faculty of Science and the Leiden Academic Center for Drug Research (LACDR) at Leiden University are recruiting for a PhD: PhD Candidate in Quantitative Pharmacology of Antimicrobial Combination Therapies (1.0 working days). Vacancy number: 15471.We are looking for an ambitious PhD student to join the Department of Systems Pharmacology and Pharmacy (LACDR) at Leiden University. The successful PhD student will carry out innovative research in the field of quantitative antimicrobial pharmacology and pharmacometrics, with a primary focus on the design of innovative antimicrobial drug combination therapies. Antimicrobial drug combinations are critical for combating antimicrobial resistance (AMR) and treating complex infections. However, selecting the right combination and optimizing its dosing schedule to maximize efficacy and minimize the risk of AMR selection is a challenging task that requires extensive preclinical development. To streamline this process, there is an urgent need for standardized methods for integrating experimental assays and computational models. This PhD project, funded by JPIAMR, aims to develop a toolbox of experimental and pharmacometric methods to improve the design and evaluation of antibiotic combination therapies. We are looking for a PhD candidate with an interest and experience in quantitative pharmacological modeling. In addition to developing pharmacological models, the candidate will be involved in the design and implementation of ancillary in vitro experiments to support model development. This project will be carried out in close collaboration with academic partners at the University of Hamburg, University of Poitiers, University of Copenhagen and University College London.
offer requirements
A Master’s degree in (bio)pharmaceutics, biomedical sciences, pharmacy or (quantitative) biology, or a similar Master’s degree. Knowledge of PK/PD and (clinical) pharmacology. Knowledge of infectious diseases, microbiology and antimicrobial pharmacology is desirable. Hands-on experience in PK/PD modeling and/or mechanistic computational biological modeling. Hands-on experience using scientific scripting languages (R, Python). Hands-on laboratory experience, preferably in microbiological assays, or a strong interest in gaining experience in this area during the PhD program. Creative / divergent thinking. Fully proficient in English (IELTS/TOEFL scores if available). Strong communication and writing skills. Ability to work independently and in a team. Excellent organizational and planning skills. Interested in participating in educational assignments.
offer benefits/salary
We offer a one-year full-time position. The appointment will be extended for an additional three years after a positive assessment of research progress, teaching evaluation, personal competence and compatibility. You will be employed under the NLU Collective Labor Contract. The monthly salary is €2,901 in the first year and €3,707 in the fourth year (P salary). Leiden University offers an attractive benefits package including additional vacation (8%) and year-end bonus (8.3%), training and career development. Our individual choice model offers you a degree of freedom to set your own terms and conditions. We have a dual career program for international spouses. Candidates from outside the Netherlands are entitled to significant tax deductions. All our PhD students study at the Leiden University Graduate School of Science. Our Graduate School offers doctoral training programs at three levels: professional courses, skills training and personal effectiveness. In addition, the Graduate School offers advanced courses to deepen your scientific knowledge.